Three Kratom Compounds Are Already Schedule I. The Big One Is Still Pending.

The ban that already happened

On August 26 the DEA placed three kratom-derived compounds - mitragynine pseudoindoxyl, MGM-15 and MGM-16 - into Schedule I. No phase-in, no grace period: the temporary order took effect the day it published and runs through August 26, 2028.

These are not what's in a bag of leaf. All three are laboratory products, and the DEA's rationale leans on the harm it attributes to them - 56 overdose cases tied to mitragynine pseudoindoxyl, 48 of them fatal, plus 17 cases and 16 deaths for MGM-15, as of May 2026. The agency also pointed to kratom-related poison center calls climbing from 258 in 2015 to 3,434 in 2025, north of 1,200%.

The ban that hasn't

The bigger action is still sitting in a drawer. On July 6 the DEA filed a notice of intent to temporarily schedule 7-hydroxymitragynine - 7-OH - above a specified threshold: more than 0.050% by weight, or more than 1.00 milligram per article. That one reaches botanical material too, if it tests above 0.050% on a dry weight basis.

DEA said an order could follow on or after August 5. It still hasn't issued. Meanwhile HHS ran a public comment window on the threshold itself and extended the deadline to September 10 - which closed two days ago. Those comments go to the Attorney General for consideration.

Why the threshold matters: by the DEA's own account, 7-OH occurs in natural leaf only in trace amounts, under two percent of total alkaloid content. The line is drawn to catch concentrates, extracts and "enhanced" tablets - not a scoop of plain leaf.

What this looks like in South Carolina

South Carolina already has a kratom law on the books. The Kratom Consumer Protection Act, Act 35, was signed May 12, 2025 and took effect that July: 21-and-over only, and every product must carry a label stating how much mitragynine and 7-hydroxymitragynine it contains.

Which turns out to be quietly useful right now. The number the federal rule would key on is printed on the package. Read it.

Sources

Educational content, not legal advice. Laws change - verify with official sources.

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